|
KMID : 1138720210470030001
|
|
Korean Public Health Research
2021 Volume.47 No. 3 p.1 ~ p.10
|
|
|
Potential Hypotheses for Explaining the Association between Circulating 25-Hydroxyvitamin D levels and Prostate Cancer Risk
|
|
Bae Jong-Myon
|
|
|
Abstract
|
|
|
Objectives: Consistent inverse relationships between circulating vitamin D level and risk of colorectal cancer and breast cancer were found. However, previous systematic reviews reported that higher circulating vitamin D level increases the prostate cancer risk. In this meta-epidemiological review, the author will summarize the results of previous systematic reviews evaluating the association between circulating 25-hydroxyvitamin D levels and prostate cancer risk.
Methods: The subjects were previous systematic reviews for evaluating the association between serum vitamin D levels and prostate cancer risk. To suggest some new hypotheses, an updated dose-response meta-analysis for follow-up studies was conducted.
Results: Previous systematic reviews showed that many epidemiological studies published before 2014 had investigated the hypothesis about the increased risk of prostate cancer associated with vitamin D deficiency/insufficiency. However, the opposite results of the previous hypothesis were derived as the number of papers selected for meta-analysis exceeded 19. Subgroup analysis by study design showed that significant results showed in 17 nested case-control studies and in five follow-up studies. Dose-response meta-analysis had a statistical significance in nested case-control studies, not in follow-up studies.
Significance of Results: Six major hypotheses such as heterogeneity of prostate cancer, a healthy screened bias, a non-linear U-shaped relationship, a tumor-promoting effects of vitamin D, the engaging effect of vitamin D in initiation or progression stage, and some single-nucleotide polymorphisms of the vitamin D receptor gene, have been suggested about how vitamin D has an opposite direction of risk between the prostate and other cancers.
|
|
|
KEYWORD
|
|
|
Vitamin D, prostate neoplasm, meta-analysis, systematic review
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|